Sitio en Español

Manuel J. Aybar, PhD     

Dept. of Developmental Biology,

INSIBIO (CONICET-UNT)  

and     

Faculty of Biochemistry, Chemistry and Chemistry

National University of Tucumán

Chacabuco 461

T4000 ILI - San Miguel de Tucumán

Argentina

Fax: +54-381-4247752 ext. 7004

Tel: +54-381-42107214

Email: mjaybar#fbqf.unt.edu.ar (# = @)

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Professional Interests

Genes and cell signaling pathways involved in the establishment of different cell lineages derived from the neural crest.

Teaching Interests

Developmental Genetics; Human Anatomy and Embryology; Graduate Programs in Biochemistry

Education

• Biochemist, National University of Tucumán, Argentina, 1993
• PhD in Biochemistry, National University of Tucumán, Argentina, 1998
• Postdoctoral Fellow, Inst. of Biology, Faculty of Biochemistry, Chemistry and Pharmacy, National University of Tucumán, Argentina, 1998-2000
• Postdoctoral Fellow, Millenium Nucleus in Developmental Biology, ICM-Mideplan, Faculty of Sciences, University of Chile, Chile, 2000-2003.

Current positions

• Assistant Professor, Faculty of Biochemistry, Chemistry and Pharmacy, National University of Tucumán
• Assistant Researcher, Conicet Scientific Researcher Career
• Researcher, Millenium Nucleus in Developmental Biology, ICM-Mideplan, Chile

Selected publications

• Participation of GM1 ganglioside in Bufo arenarum gastrulation. Manuel J. Aybar, Susana B. Genta, Alicia Sánchez Riera, Sara S. Sánchez. J. Exp. Zool. (2000) 286:457-472.

• Induction and development of neural crest in Xenopus laevis. Roberto Mayor, Manuel J. Aybar. Cell Tissue Research (2001) 305:203-209. Review.

• Early induction of neural crest cells: lessons learned from frog, chick and fish. Manuel J. Aybar, Roberto Mayor. Current Opinion in Genetics and Development  (2002) 12:452-458. Review.

• Snail precedes Slug in the genetic cascade required for the specification and migration of the Xenopus neural crest. Manuel J. Aybar, M. Angela Nieto, Roberto Mayor. Development (2003) 130:483-494.

• Sox10 is required for the early development of the prospective neural crest in Xenopus embryos. Stella Maris Honoré, Manuel J. Aybar, Roberto Mayor. Developmental Biology (2003) 260:79-96. 

• Regulation of msx1 by a BMP gradient is essential for neural crest specification. Celeste Tríbulo, Manuel J. Aybar, Vu H. Nguyen, Mary C. Mullins, Roberto Mayor. Development (2003), 130:6441-6452.

• A balance between the anti-apoptotic activity of slug and the apoptotic activity of msx1 is required for the proper development of the neural crest. Celeste Tríbulo, Manuel J. Aybar, Sara S. Sánchez, Roberto Mayor. Developmental Biology (2004) 275:325-342.

Grants received

• 2005-2007. Conicet (Argentina), "Edn/Ednra cell signaling pathway in Xenopus neural crest development".
• 2005-2008. Foncyt-UNT-PICTO (Argentina), "Edn pathway in the control of gene expression during development".
• 2004-2006. Millenium Nucleus in Developmental Biology, ICM-Mideplan (Chile) "Research Nucleus for Developmental Biology and Genetic Engineering in Animal Models".
• 2004-2006. Foncyt-PICT (Argentina), "Molecular analysis of neural crest lineage generation in amphibians: basic and applied research".
• 2004-2005. UNSTA (Argentina), UNSTA Research Council Grant.
• October 2003. Turner BioSystems Fluorometer Grants Program, USA. 

• 2003-2005. Fundación Antorchas (Argentina). Molecular analysis of the lineage establishment and differentiation in the neural crest of Xenopus laevis. Reentry grant.

• 2001-2004. CIUNT (Research Council of National University of Tucumán, Argentina). “Cell interactions during amphibian development”.

• 2001-2003. Fondecyt (Chile), “Modulation of neural induction by elements of the extracellular matrix”.

• 2001-2002. Fundación Antorchas (Argentina), “Molecular analysis of neural crest differentiation in Xenopus laevis”. For scientific collaboration with Dr. Roberto Mayor, University of Chile.

• 2000-2001. Fundación Antorchas (Argentina), “Molecular analysis of neural crest differentiation in Xenopus laevis”. For scientific collaboration with Dr. Roberto Mayor, University of Chile.

• 1999-2003. Foncyt-PICT (Argentina). “Glycosphingolipids in the amphibian embryogenesis”. Grant for young researchers.  

Society memberships

• Society for Developmental Biology, USA.

• American Association of Anatomists, USA.

• Latin American Society for Developmental Biology.

• Asociación de Biología de Tucumán, Argentina.

• Asociación Argentina de Biología del Desarrollo, Argentina.

The sponsors of our research:

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